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KMID : 0387420190300020071
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Korean Society of Oriental Neuropsychiatry
2019 Volume.30 No. 2 p.71 ~ p.88
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A Review of the Korean Experimental Studies on the Antidepressant Effect of Herbal Medicines
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Han Da-Young
Kim Sang-Ho
Chung Dae-Kyoo
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Abstract
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Objectives: The present study aims to review the antidepressant effect of herbal medicines reported in Korean local journals.
Methods: We searched in electronic databases (Koreantk, KISS, OASIS, NDSL) for studies, published in Korean national journals, that assessed herbal medicine effect of depression model. The search term was ‘depression’ in the abstract or whole text. Depression model, herbal material, experimental results, mechanisms were extracted.
Results: We included 43 articles in which 38 studies were in vitro experiments, and the rest 5 were in vivo experiments. The most common experiment subject model was a rat and the most widely used method to induce depression was Despair behavior test. 21 studies used simple herbal medicines, and 22 studies used complex herbal medication. Glycyrrhizae Radix was the most commonly used herbal material to improve depression model. The most common mechanisms of herbal medicine with anti-depressant effect were inhibition of Monoamine activation mechanism and depression related neuro-hormone secretion.
Conclusions: Herbal medicines may be a promising resource for treating depression.
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KEYWORD
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Depression, Depressive disorder, Herbal medicine, Antidepressant, Review
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